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Please use this identifier to cite or link to this item: https://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/3870
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dc.contributor.authorCollins, Ian M.-
dc.contributor.authorDall, Genevieve-
dc.contributor.authorVandenberg, Cassandra J.-
dc.contributor.authorNesic, Ksenija-
dc.contributor.authorRatnayake, Gayanie-
dc.contributor.authorZhu, Wenying-
dc.contributor.authorVissers, Joseph H. A.-
dc.contributor.authorBedo, Justin-
dc.contributor.authorPenington, Jocelyn-
dc.contributor.authorWakefield, Matthew J.-
dc.contributor.authorKee, Damien-
dc.contributor.authorCarmagnac, Amandine-
dc.contributor.authorLim, Ratana-
dc.contributor.authorShield-Artin, Kristy-
dc.contributor.authorMilesi, Briony-
dc.contributor.authorLobley, Amanda-
dc.contributor.authorKyran, Elizabeth L.-
dc.contributor.authorO'Grady, Emily-
dc.contributor.authorTram, Joshua-
dc.contributor.authorZhou, Warren-
dc.contributor.authorNugawela, Devindee-
dc.contributor.authorStewart, Kym Pham-
dc.contributor.authorCaldwell, Reece-
dc.contributor.authorPapadopoulos, Lia-
dc.contributor.authorNg, Ashley P.-
dc.contributor.authorBarker, Holly E.-
dc.contributor.authorDobrovic, Alexander-
dc.contributor.authorFox, Stephen B.-
dc.contributor.authorMcNally, Orla-
dc.contributor.authorPower, Jeremy D.-
dc.contributor.authorMeniawy, Tarek-
dc.contributor.authorHan Tan, Teng-
dc.contributor.authorKlein, Oliver-
dc.contributor.authorBarnett, Stephen-
dc.contributor.authorOlesen, Inger-
dc.contributor.authorHamilton, Anne-
dc.contributor.authorHofmann, Oliver-
dc.contributor.authorGrimmond, Sean-
dc.contributor.authorPapenfuss, Anthony T.-
dc.contributor.authorScott, Clare L.-
dc.date.accessioned2023-05-11T23:38:09Z-
dc.date.available2023-05-11T23:38:09Z-
dc.date.issued2023-05-04-
dc.identifier.issn1756-9966en
dc.identifier.urihttps://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/3870-
dc.description.abstractUterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of < 10%. Mutations in the homologous recombination (HR) DNA repair pathway have been observed in ~ 10% of uLMS cases, with reports of some individuals benefiting from poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) therapy, which targets this DNA repair defect. In this report, we screened individuals with uLMS, accrued nationally, for mutations in the HR repair pathway and explored new approaches to therapeutic targeting.en
dc.subjectCanceren
dc.subjectLeiomyosarcomaen
dc.subjectUterineen
dc.subjectGynaecologyen
dc.subjectuLMSen
dc.subjectDNAen
dc.titleTargeting homologous recombination deficiency in uterine leiomyosarcomaen
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Experimental & Clinical Cancer Researchen
dc.accession.number112en
dc.identifier.urlhttps://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02687-0en
dc.description.affiliationSouthWest Healthcare, Warrnambool, VIC, 3280, Australiaen
dc.description.affiliationWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia-
dc.description.affiliationDepartment of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia-
dc.description.affiliationRoyal Women’s Hospital, Parkville, VIC, 3052, Australia-
dc.description.affiliationCentre for Cancer Research and Department of Clinical Pathology, University of Melbourne, Parkville, VIC, 3010, Australia-
dc.description.affiliationSchool of Computing and Information Systems, the University of Melbourne, Parkville, VIC, 3010, Australia-
dc.description.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia-
dc.description.affiliationAustin Health, Heidelberg, VIC, 3084, Australia-
dc.description.affiliationAustralian Rare Cancer Portal, BioGrid Australia, Melbourne Health, Parkville, VIC, 3052, Australia-
dc.description.affiliationPeter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, 3010, Australia-
dc.description.affiliationRoyal Melbourne Hospital, Parkville, VIC, 3052, Australia-
dc.description.affiliationDepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC, 3010, Australia-
dc.description.affiliationLaunceston General Hospital, Launceston, TAS, 7250, Australia-
dc.description.affiliationUniversity of Western Australia, Perth, WA, 6009, Australia-
dc.description.affiliationSouthWest Healthcare, Warrnambool, VIC, 3280, Australia-
dc.description.affiliationFaculty of Health, School of Medicine, Deakin University, Warrnambool, VIC, 3280, Australia-
dc.description.affiliationWestern Hospital, Footscray, VIC, 3011, Australia-
dc.description.affiliationUniversity Hospital Geelong, Geelong, VIC, 3220, Australia-
dc.source.volume42en
local.issue.number112en
dc.format.pages20en
dc.identifier.importdoi10.1186/s13046-023-02687-0en
dc.identifier.date2023-
dc.contributor.swhauthorCollins, Ian M.-
dc.contributor.swhauthorKlein, Oliver-
dc.relation.departmentOncology-
Appears in Collections:SWH Staff Publications

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