Please use this identifier to cite or link to this item: https://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/4214
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dc.contributor.authorMunter, Karl-Christian-
dc.contributor.authorLazaro-Martinez, Jose-
dc.contributor.authorKanya, Susanne-
dc.contributor.authorSawade, Linda-
dc.contributor.authorSchwenke, Carsten-
dc.contributor.authorPegalajar-Jurado, Adoracion-
dc.contributor.authorSwanson, Terry-
dc.contributor.authorLeaper, David-
dc.date.accessioned2024-10-21T03:45:56Z-
dc.date.available2024-10-21T03:45:56Z-
dc.date.issued2024-10-02-
dc.identifier.issn0969-0700en
dc.identifier.urihttps://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/4214-
dc.description.abstractAbstract Objective: Delayed or stalled healing in open wounds can result from persisting chronic inflammation related to infection and/or persistent bacterial colonisation and biofilm. Treatment of hard-to-heal wounds focuses on debridement and exudate management, but also on infection prevention and control. Silver dressings have been evaluated in randomised clinical trials (RCTs); this meta-analysis evaluated the efficacy and safety of a silver ion-releasing foam dressing (Biatain Ag; Coloplast A/S, Denmark) to treat hard-to-heal wounds. Method: Literature databases (PubMed and Cochrane Library) were searched for studies on silver ion-releasing foam dressings in the treatment of hard-to-heal wounds. Individual patient data from four RCTs were obtained and included in the meta-analysis. Results: Findings showed that treatment with the silver ion-releasing foam dressing was associated with a significantly higher relative reduction in wound area after four (least squares-mean difference (LS-MD): –12.55%, 95% confidence interval (CI): (–15.95, –9.16); p<0.01) and six weeks of treatment (LS-MD: –11.94%, 95%CI: (–17.21, –6.68); p<0.01) compared with controls. Significant benefits were also observed for time to disappearance of odour (hazard ratio: 1.61, 95%CI: (1.31, 1.98); p<0.01), relative reduction of exudate (LS-MD: –5.15, 95%CI: (–7.36, –2.94); p<0.01), proportion of patients with periwound erythema (relative risk (RR): 0.81, 95%CI: (0.69; 0.94); p<0.01), and less pain at dressing removal (LS-MD: –0.35, 95%CI: (–0.63, –0.06); p=0.02). No differences regarding safety outcomes were identified. Conclusion: This meta-analysis has demonstrated beneficial outcomes and a good tolerability profile for silver ion-releasing foam dressings in the treatment of moderate-to-highly exuding wounds with delayed healing compared with control dressings.en
dc.subjectSilver ion-releasing foamen
dc.subjectFoam dressingen
dc.subjectHard-to-heal woundsen
dc.subjectMeta-analysisen
dc.subjectDelayed healingen
dc.subjectSilver Dressingsen
dc.subjectStalled Healingen
dc.subjectOpen woundsen
dc.subjectWoundsen
dc.titleClinical efficacy and safety of a silver ion-releasing foam dressing on hard-to-heal wounds: a meta-analysisen
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Wound Careen
dc.accession.numberhttps://doi.org/10.12968/jowc.2024.0149en
dc.identifier.urlhttps://www.magonlinelibrary.com/doi/full/10.12968/jowc.2024.0149en
dc.source.volume33en
local.issue.number10en
dc.identifier.importdoihttps://doi.org/10.12968/jowc.2024.0149en
dc.identifier.date2024-10-10-
dc.contributor.swhauthorSwanson, Terry-
Appears in Collections:SWH Staff Publications

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