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DC Field | Value | Language |
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dc.contributor.author | Munter, Karl-Christian | - |
dc.contributor.author | Lazaro-Martinez, Jose | - |
dc.contributor.author | Kanya, Susanne | - |
dc.contributor.author | Sawade, Linda | - |
dc.contributor.author | Schwenke, Carsten | - |
dc.contributor.author | Pegalajar-Jurado, Adoracion | - |
dc.contributor.author | Swanson, Terry | - |
dc.contributor.author | Leaper, David | - |
dc.date.accessioned | 2024-10-21T03:45:56Z | - |
dc.date.available | 2024-10-21T03:45:56Z | - |
dc.date.issued | 2024-10-02 | - |
dc.identifier.issn | 0969-0700 | en |
dc.identifier.uri | https://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/4214 | - |
dc.description.abstract | Abstract Objective: Delayed or stalled healing in open wounds can result from persisting chronic inflammation related to infection and/or persistent bacterial colonisation and biofilm. Treatment of hard-to-heal wounds focuses on debridement and exudate management, but also on infection prevention and control. Silver dressings have been evaluated in randomised clinical trials (RCTs); this meta-analysis evaluated the efficacy and safety of a silver ion-releasing foam dressing (Biatain Ag; Coloplast A/S, Denmark) to treat hard-to-heal wounds. Method: Literature databases (PubMed and Cochrane Library) were searched for studies on silver ion-releasing foam dressings in the treatment of hard-to-heal wounds. Individual patient data from four RCTs were obtained and included in the meta-analysis. Results: Findings showed that treatment with the silver ion-releasing foam dressing was associated with a significantly higher relative reduction in wound area after four (least squares-mean difference (LS-MD): –12.55%, 95% confidence interval (CI): (–15.95, –9.16); p<0.01) and six weeks of treatment (LS-MD: –11.94%, 95%CI: (–17.21, –6.68); p<0.01) compared with controls. Significant benefits were also observed for time to disappearance of odour (hazard ratio: 1.61, 95%CI: (1.31, 1.98); p<0.01), relative reduction of exudate (LS-MD: –5.15, 95%CI: (–7.36, –2.94); p<0.01), proportion of patients with periwound erythema (relative risk (RR): 0.81, 95%CI: (0.69; 0.94); p<0.01), and less pain at dressing removal (LS-MD: –0.35, 95%CI: (–0.63, –0.06); p=0.02). No differences regarding safety outcomes were identified. Conclusion: This meta-analysis has demonstrated beneficial outcomes and a good tolerability profile for silver ion-releasing foam dressings in the treatment of moderate-to-highly exuding wounds with delayed healing compared with control dressings. | en |
dc.subject | Silver ion-releasing foam | en |
dc.subject | Foam dressing | en |
dc.subject | Hard-to-heal wounds | en |
dc.subject | Meta-analysis | en |
dc.subject | Delayed healing | en |
dc.subject | Silver Dressings | en |
dc.subject | Stalled Healing | en |
dc.subject | Open wounds | en |
dc.subject | Wounds | en |
dc.title | Clinical efficacy and safety of a silver ion-releasing foam dressing on hard-to-heal wounds: a meta-analysis | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Journal of Wound Care | en |
dc.accession.number | https://doi.org/10.12968/jowc.2024.0149 | en |
dc.identifier.url | https://www.magonlinelibrary.com/doi/full/10.12968/jowc.2024.0149 | en |
dc.source.volume | 33 | en |
local.issue.number | 10 | en |
dc.identifier.importdoi | https://doi.org/10.12968/jowc.2024.0149 | en |
dc.identifier.date | 2024-10-10 | - |
dc.contributor.swhauthor | Swanson, Terry | - |
Appears in Collections: | SWH Staff Publications |
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